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A good item in Isaac can save a race. The best items can win a race.
5. Death certificate
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This item really shouldn't be on the list, but that's simply because it's technically the literal best item in the game. Death Certificate takes you to a special floor where you can choose any item you want. Any item you want in the game, except for a few. By definition, an item that guarantees you the best item in the game is as good as the best item in the game.
4. Dead Cat
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The effect of Dead Cat is very simple; it gives you nine lives. Since you normally only have one life, you can abuse your new longevity in Demon Halls to get top tier items. It's also a boon for tough characters like The Lost, who normally die in the blink of an eye. Just be careful when picking it up; it sets your heart containers to one when picking up.
Related: How to Unlock Downpour in Binding of Isaac Repentance
3. Holy Mantle
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A free hit in each room may not seem like much, but this flea damage easily accumulates over time. It also allows you to enter and exit Curse Rooms for free, giving you access to a new source of items and resources for free.
2. Divinity
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The task of unlocking Godhead is no joke, but once you've done it, you have one of Isaac's finest items. Massive damage, a damaging holy aura around your tears, and a rallying effect, what more could you want from a single item?
1. R button
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Want access to a full suite of shops, item rooms, boss items, chances to negotiate with angels and demons, and everything else that comes with a run? Want to beat both??? and the Lamb in the same course? Well, there it is. All it costs you is your active item and your time. Good luck.
For help on something that's definitely not the best in the game, check out All Pandora's Box effects in The Binding of Isaac on Thekingplayers!
