The Ranger/Poison/Defender composition got much better in 10.1 and now stands out as one of the best in the meta.
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The Ranger / Poison / Defender composition
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| Varus | Kindred | Ashe | Twitch | Dr. World | singed | taric | amumu |
 Prowler (4) |
Rangers have an 80% chance of doubling their attack speed every 3 seconds. |
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Increases armor of all Defenders by 150%. |
 Poison (3) |
Poison units apply a neurotoxin when they damage a target, increasing its mana cost by 50%. |
 Cristal (2) |
Crystal units cannot take more than 100 damage at once. |
 Hells (3) |
Underworld champion critical hits and spells burn the ground beneath the target, dealing 70% initial damage over 4 seconds. |
Defender (2)This composition is based on Prowlers which were greatly improved in 9.24. The two main carries are Ashe et Twitch for damage, but it's also interesting to equip tank items on one of your Défenseurs, usually taric level 2.
This is a composition to consider if you have a lot of 
Curved arches and 
Training gloves in particular.
Preferred items
Twitch |
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 Last breath |
 Infinity blade |
 Mercury |
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Since his buff in 10.1, Twitch returned to main carry, notably thanks to its ability to apply the armor debuff of the Last breath to multiple targets, allowing Prowlers to melt the opposing frontline. With this object, the Infinity blade will give him 65% critical chance in total in addition to boosting their damage. The third object will usually be defensive, the Mercury being very strong to avoid him being controlled. Alternatively, Twitch can also use control objects, like |
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Hush, 
sword breaker ou 
Frozen Mallet (With Ezreal for example), in order to apply them on a maximum of targets at the same time. A second Infinity Edge is also to be considered.Ashe |
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 Dagger of Statikk |
Dagger of Statikk |
 hand of justice |
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The Prowlers generally lack area damage, which is why the Dagger of Statikk is very effective. Since they attack very quickly, they use this item wonderfully, and it will usually be Ashe who will benefit from it in this composition. The hand of justice can not only increase the damage of the Statikk, but also heal Ashe depending on which effect is activated, both of which are very interesting. If she can just equip two Statikk Daggers, other items can go on Ashe. Against a lot of tanks, a combination of |
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Giant Slayer et 
Ouragan de Runaan will be very strong for example. She can also use other items, ranging from healing the 
Thirst for blood to the critics of 
Infinity blade, through the utility of the taric |
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 Guardian angel |
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L'Guardian angel allows to taric to guarantee the use of his ultimate, especially if he is not level 2. He can also use other defensive objects, such as the |
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Warmog, living armor or 
Gripper trap for example. These objects can also go on amumu if you have it level 2 before Taric.Last but not least, singed works great with a 
morellonomicon, which he can apply to the entire opposing team.
Start of the game and progress
At the start of the game, you may have a frontline of Défenseurs (Nasus, Ornn, Braum, Thresh...) to which you will add two Rangers: often Vayne et Varus. The first will be very important, since it will serve as your carry until the middle of the game, carrying the items that will then be given to Ashe or to Twitch.
It is also possible to use the element Lightning at the start of the game, with Ornn et volibear coupled to Brew for three interesting synergies (with Défenseur et Glacial). Both Lunars are also essential at the start of the game, especially Karma which will boost the attack speed of one of your Prowlers.
The goal will always be to add a new pair according to what you have the most, since you will have the choice among 6 Prowlers and 8 Défenseurs different the time to find all those of the final composition. At level 4, you will usually have 2 Defenders + 2 Rangers, then you will have either 4 Defenders and 2 Rangers, or the reverse at level 6. It is also possible to have 2 Rangers, 2 Defenders and 2 Mystics with Karma et Soraka.
If it is possible to use many transition units (Thresh et Nautilus for taric for example, Skarner at level 7 for the bonus Glass, Kog'Maw for Poison...), it will be important to reach level 8 quickly in order to maximize your chances of obtaining your two legendary units. They are essential if you want to make top 1 with this composition.
Endgame and transitions
The compos Prowlers can be played in many different ways. If now, the most popular version uses Posound with singed et Dr. World and Lunar et Mystique with Karma, Leona et Nami, there are many replaceable units.
 Leona |
 Karma |
Ashe |
Twitch |
Dr. World |
singed |
taric |
 Nami |
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If you Mystics, you can replace the 4 Rangers by Lunar, which will be stronger in the mid-game. Karma will allow you not to lose too much DPS on your Twitch thanks to its attack speed boost. |
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Varus |
Kindred |
Ashe |
Twitch |
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taric |
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It is also possible to play without Poison if you can't find singed or that you are against a lot of Blade Masters and Berzerkers for example, who do not particularly benefit from their spells. In this situation, add 2 Défenseurs or 2 MysticsOr Lunar, may be more interesting. |
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If you opted for the version 4 Defenders, with a Spatula, you can also make a 
Guardian's Mail, which will allow you to separate from one of your guardians (usually Brew) and enter a total of 6 Rangers at level 9. It is also possible to have 6 Defenders in place.
If you can pass level 9, several options are interesting as a last unit. The best is probably Lux Crystal, which will make your taric et Ashe very difficult to kill. If you have 
Ashes of Hell, Lux Hells can sometimes give you the bonus 6 of this synergy, greatly increasing your area damage.
Positioning Tips
It may be interesting to have taric further back than the other tanks, so that he can hit more targets with his ultimate from his central position. Among the tanks, you will generally want to have the one equipped closest to the opponents so that it receives maximum focus.
Si Ashe et Twitch are in the middle, they are also less likely to be targeted quickly by the opposing team with Kindred et Varus on the coast.
This positioning can be modified according to the Elementary boxes. This comp works best on cards Underworld, since the attack speed bonus will be very strong for Prowlers, but also on the maps Mountain to boost the HP of your Défenseur equipped with defensive items.
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